CC-647
CC-647 is a molecular glue modulator targeting Cereblon (CRBN) E3 ubiquitin ligase. CC-647 promotes the interaction between CRBN and ZBTB16 as well as its oncogenic fusion protein RARα-ZBTB16 (with a DC50 of 103 nM) . CC-647 is promising for research of ZBTB16-RARα-associated acute promyelocytic leukemia (APL) [1].
Product Specifications
CAS Number
[1061605-35-3]
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; Molecular Glues
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Field of Research
Cancer
Purity
99.58
Solubility
DMSO : 35 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(OC4=CC=CC(C(C)(C)C)=C4)=CC=C2
Molecular Formula
C23H22N2O5
Molecular Weight
406.43
References & Citations
[1]Matyskiela ME, et al. Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons. ACS Chem Biol. 2020 Dec 18;15 (12) :3149-3158.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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