CC-647

CC-647 is a molecular glue modulator targeting Cereblon (CRBN) E3 ubiquitin ligase. CC-647 promotes the interaction between CRBN and ZBTB16 as well as its oncogenic fusion protein RARα-ZBTB16 (with a DC50 of 103 nM) . CC-647 is promising for research of ZBTB16-RARα-associated acute promyelocytic leukemia (APL) [1].

Product Specifications

CAS Number

[1061605-35-3]

UNSPSC

12352005

Target

E1/E2/E3 Enzyme; Molecular Glues

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Field of Research

Cancer

Purity

99.58

Solubility

DMSO : 35 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(OC4=CC=CC(C(C)(C)C)=C4)=CC=C2

Molecular Formula

C23H22N2O5

Molecular Weight

406.43

References & Citations

[1]Matyskiela ME, et al. Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons. ACS Chem Biol. 2020 Dec 18;15 (12) :3149-3158.