FAK-IN-27
FAK-IN-27 (compound 8A) is a potent and selective FAK inhibitor with an IC50 of 4.968 nM. FAK-IN-27 suppresses H1299 cells proliferation with an IC50 of 0.28 μM. FAK-IN-27 can be used in the study of NSCLC[1].
Product Specifications
UNSPSC
12352005
Target
FAK
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
ClC1=C(NC2=C(C(NC)=O)C=CC=C2)N=C(NC3=CC=C(CC(OCCCOC4=CC=C(C=CC(O5)=O)C5=C4)=O)C=C3)N=C1
Molecular Formula
C32H28ClN5O6
Molecular Weight
614.05
References & Citations
[1]Lei M, et al. Design, synthesis and biological evaluation of coumarin-containing 2,4-diphenylpyrimidine derivatives as novel focal adhesion kinase inhibitors for treatment of non-small cell lung cancer. Bioorg Med Chem Lett. 2025 Aug 1;123:130240.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-173603/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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