FAK-IN-27

FAK-IN-27 (compound 8A) is a potent and selective FAK inhibitor with an IC50 of 4.968 nM. FAK-IN-27 suppresses H1299 cells proliferation with an IC50 of 0.28 μM. FAK-IN-27 can be used in the study of NSCLC[1].

Product Specifications

UNSPSC

12352005

Target

FAK

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

ClC1=C(NC2=C(C(NC)=O)C=CC=C2)N=C(NC3=CC=C(CC(OCCCOC4=CC=C(C=CC(O5)=O)C5=C4)=O)C=C3)N=C1

Molecular Formula

C32H28ClN5O6

Molecular Weight

614.05

References & Citations

[1]Lei M, et al. Design, synthesis and biological evaluation of coumarin-containing 2,4-diphenylpyrimidine derivatives as novel focal adhesion kinase inhibitors for treatment of non-small cell lung cancer. Bioorg Med Chem Lett. 2025 Aug 1;123:130240.