FAK-IN-27
FAK-IN-27 (compound 8A) is a potent and selective FAK inhibitor with an IC50 of 4.968 nM. FAK-IN-27 suppresses H1299 cells proliferation with an IC50 of 0.28 μM. FAK-IN-27 can be used in the study of NSCLC[1].
Product Specifications
UNSPSC
12352005
Target
FAK
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
ClC1=C(NC2=C(C(NC)=O)C=CC=C2)N=C(NC3=CC=C(CC(OCCCOC4=CC=C(C=CC(O5)=O)C5=C4)=O)C=C3)N=C1
Molecular Formula
C32H28ClN5O6
Molecular Weight
614.05
References & Citations
[1]Lei M, et al. Design, synthesis and biological evaluation of coumarin-containing 2,4-diphenylpyrimidine derivatives as novel focal adhesion kinase inhibitors for treatment of non-small cell lung cancer. Bioorg Med Chem Lett. 2025 Aug 1;123:130240.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
131806-AP 100 µL
PRKCQ (Protein Kinase C theta Type, nPKC-theta, PRKCT, MGC126514, MGC141919) (AP) discontinued
Ask
View Details MBS1072161-01 1 mg (E-Coli)
Recombinant Bovine herpesvirus 4 Probable E3 ubiquitin-protein ligase IE1 (IE1), partial
Ask
View Details MBS1072161-02 1 mg (Yeast)
Recombinant Bovine herpesvirus 4 Probable E3 ubiquitin-protein ligase IE1 (IE1), partial
Ask
View Details 