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JAK3-IN-17

JAK3-IN-17 (Compound X15) is an orally active JAK3 inhibitor (IC50: 14.56 nM) . JAK3-IN-17 inhibits the production of IL-2 and IL-6 in a DNCB-induced mouse atopic dermatitis model and exhibits anti-inflammatory activity[1].

Product Specifications

UNSPSC

12352005

Target

JAK

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(C=C)NC1=CC=CC(C2=CN=C3C=CC(C4=C(F)N=CC=C4)=CN32)=C1

Molecular Formula

C21H15FN4O

Molecular Weight

358.37

References & Citations

[1]Ren W, et al. Discovery of novel JAK3 inhibitors for the treatment of atopic dermatitis. Bioorg Med Chem Lett. 2025 Aug 1;123:130219.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

JAK3

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