JAK3-IN-17
JAK3-IN-17 (Compound X15) is an orally active JAK3 inhibitor (IC50: 14.56 nM) . JAK3-IN-17 inhibits the production of IL-2 and IL-6 in a DNCB-induced mouse atopic dermatitis model and exhibits anti-inflammatory activity[1].
Product Specifications
UNSPSC
12352005
Target
JAK
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(C=C)NC1=CC=CC(C2=CN=C3C=CC(C4=C(F)N=CC=C4)=CN32)=C1
Molecular Formula
C21H15FN4O
Molecular Weight
358.37
References & Citations
[1]Ren W, et al. Discovery of novel JAK3 inhibitors for the treatment of atopic dermatitis. Bioorg Med Chem Lett. 2025 Aug 1;123:130219.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK3
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