SNT-8370
SNT-8370 is an orally active inhibitor of VAP-1 (IC50: 10 nM) and myeloperoxidase (MPO) (IC50: 17 nM), with >100-1000 fold more potency for VAP-1 and MPO versus other mammalian (per) oxidases. SNT-8370 inhibits MPO-mediated LDL lipid peroxidation. SNT-8370 inhibits leukocyte infiltration in lung injury models of acute inflammation. SNT-8370 is an anti-inflammatory agent, and can be used for research of inflammatory disorders[1].
Product Specifications
UNSPSC
12352005
Target
Glutathione Peroxidase; VAP-1
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C1C2=C(N=CN2)N(CC3=CC=CC(OC/C(CN)=C/F)=C3)C(N1)=S
Molecular Formula
C16H16FN5O2S
Molecular Weight
361.39
References & Citations
[1]Glaros E, et al. Targeting vascular adhesion protein-1 and myeloperoxidase with a dual inhibitor SNT-8370 in preclinical models of inflammatory disease. Nat Commun. 2025 Apr 11;16 (1) :3430.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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