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RIPK1-IN-31

RIPK1-IN-31 (Compound 36) is a selective allosteric modulator of RIPK1 (receptor-interacting protein kinase 1) with an IC50 value of 16 nM. RIPK1-IN-31 is promising for research of infectious, autoimmune, and neurodegenerative diseases[1].

Product Specifications

CAS Number

2857845-45-3

UNSPSC

12352005

Target

RIP kinase

Related Pathways

Apoptosis

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Smiles

O=C(C(C(F)F)(C)C)N1C[C@H]2OC3=C(C#N)C=NC=C3[C@@H]1C2

Molecular Formula

C15H15F2N3O2

Molecular Weight

307.30

References & Citations

[1]Chen JL, et al. The Discovery of Bridged Benzoazepine Amides as Selective Allosteric Modulators of RIPK1. ACS Med Chem Lett. 2025 Apr 14;16 (5) :811-818.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

RIPK1

Frequently Asked Questions

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