RIPK1-IN-31
RIPK1-IN-31 (Compound 36) is a selective allosteric modulator of RIPK1 (receptor-interacting protein kinase 1) with an IC50 value of 16 nM. RIPK1-IN-31 is promising for research of infectious, autoimmune, and neurodegenerative diseases[1].
Product Specifications
CAS Number
[2857845-45-3]
UNSPSC
12352005
Target
RIP kinase
Related Pathways
Apoptosis
Field of Research
Infection; Inflammation/Immunology; Neurological Disease
Smiles
O=C(C(C(F)F)(C)C)N1C[C@H]2OC3=C(C#N)C=NC=C3[C@@H]1C2
Molecular Formula
C15H15F2N3O2
Molecular Weight
307.30
References & Citations
[1]Chen JL, et al. The Discovery of Bridged Benzoazepine Amides as Selective Allosteric Modulators of RIPK1. ACS Med Chem Lett. 2025 Apr 14;16 (5) :811-818.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1
Curated Selection
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