TK-684

TK-684 is a potent and selective allosteric SHP2 inhibitor with IC50 values of 2.1, > 1000 nM for SHP2WT, SHP22PTP, respectively. TK-684 inhibits cell proliferation and induces apoptosis. TK-684 decreases the protein expression of p-AKT, p-ERK[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; SHP2

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

ClC1=C(N=CC=C1SC2=NNC(N=C(N3)N4CCC(C)(CC4)CN)=C2C3=O)N

Molecular Formula

C17H21ClN8OS

Molecular Weight

420.92

References & Citations

[1]Song Y, et al. Structure-Guided Design of Pyrazolopyrimidinones as Highly Potent and Selective Allosteric SHP2 Inhibitors. J Med Chem. 2025 Apr 16.