TK-684
TK-684 is a potent and selective allosteric SHP2 inhibitor with IC50 values of 2.1, > 1000 nM for SHP2WT, SHP22PTP, respectively. TK-684 inhibits cell proliferation and induces apoptosis. TK-684 decreases the protein expression of p-AKT, p-ERK[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; SHP2
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
ClC1=C(N=CC=C1SC2=NNC(N=C(N3)N4CCC(C)(CC4)CN)=C2C3=O)N
Molecular Formula
C17H21ClN8OS
Molecular Weight
420.92
References & Citations
[1]Song Y, et al. Structure-Guided Design of Pyrazolopyrimidinones as Highly Potent and Selective Allosteric SHP2 Inhibitors. J Med Chem. 2025 Apr 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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