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SKLB-11A

SKLB-11A is a selective, orally active and allosteric SIRT3 (sirtuin 3) agonist with a Kd value of 4.7 μM. SKLB-11A is highly selective for other members of the SIRT family. SKLB-11A activates autophagy-related signaling pathways, prevents mitochondrial dysfunction, improves cardiac function in Doxorubicin -induced cardiotoxicity and myocardial ischemia/reperfusion models[1].

Product Specifications

CAS Number

433953-86-7

UNSPSC

12352005

Target

Autophagy; Sirtuin

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cardiovascular Disease

Purity

99.40

Solubility

DMSO : 7.78 mg/mL (ultrasonic)

Smiles

COC(C1=C(N)N(CC2=CC=C(F)C=C2)C3=NC4=CC=CC=C4N=C31)=O

Molecular Formula

C19H15FN4O2

Molecular Weight

350.35

References & Citations

[1]Zhang D, et al. Unraveling Small Molecule-Mediated Sirtuin 3 Activation at a Distinct Binding Site for Cardioprotective Therapies. ACS Cent Sci. 2025 Apr 14;11 (5) :704-718.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SIRT3

Available Sizes

Frequently Asked Questions

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