Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

SKLB-11A

SKLB-11A is a selective, orally active and allosteric SIRT3 (sirtuin 3) agonist with a Kd value of 4.7 μM. SKLB-11A is highly selective for other members of the SIRT family. SKLB-11A activates autophagy-related signaling pathways, prevents mitochondrial dysfunction, improves cardiac function in Doxorubicin -induced cardiotoxicity and myocardial ischemia/reperfusion models[1].

Product Specifications

CAS Number

433953-86-7

UNSPSC

12352005

Target

Autophagy; Sirtuin

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cardiovascular Disease

Purity

99.40

Solubility

DMSO : 7.78 mg/mL (ultrasonic)

Smiles

COC(C1=C(N)N(CC2=CC=C(F)C=C2)C3=NC4=CC=CC=C4N=C31)=O

Molecular Formula

C19H15FN4O2

Molecular Weight

350.35

References & Citations

[1]Zhang D, et al. Unraveling Small Molecule-Mediated Sirtuin 3 Activation at a Distinct Binding Site for Cardioprotective Therapies. ACS Cent Sci. 2025 Apr 14;11 (5) :704-718.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SIRT3

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

BNIP3 (NM_004052) Human Over-expression Lysate
LY418252 100 µg

BNIP3 (NM_004052) Human Over-expression Lysate

Sign In for Pricing
View Details
Propargyl Alcohol
TRC-P762550-250ML 250 mL

Propargyl Alcohol

Sign In for Pricing
View Details
EIF3K Rabbit Polyclonal Antibody
TA370518 100 µL

EIF3K Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
NFkB p100 / p52 (NFKB2) Human Gene Knockout Kit (CRISPR)
KN401147 1 Kit

NFkB p100 / p52 (NFKB2) Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Esculin Sesquihydrate
TRC-E658958-50MG 50 mg

Esculin Sesquihydrate

Sign In for Pricing
View Details
HA Epitope Tag (YPYDVPDYA) Mouse Monoclonal Antibody [Clone ID: 5D8]
AM26678AF-N 100 µL

HA Epitope Tag (YPYDVPDYA) Mouse Monoclonal Antibody [Clone ID: 5D8]

Sign In for Pricing
View Details