SKLB-11A
SKLB-11A is a selective, orally active and allosteric SIRT3 (sirtuin 3) agonist with a Kd value of 4.7 μM. SKLB-11A is highly selective for other members of the SIRT family. SKLB-11A activates autophagy-related signaling pathways, prevents mitochondrial dysfunction, improves cardiac function in Doxorubicin (HY-15142A) -induced cardiotoxicity and myocardial ischemia/reperfusion models[1].
Product Specifications
CAS Number
[433953-86-7]
UNSPSC
12352005
Target
Autophagy; Sirtuin
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cardiovascular Disease
Purity
99.40
Solubility
DMSO : 7.78 mg/mL (ultrasonic)
Smiles
COC(C1=C(N)N(CC2=CC=C(F)C=C2)C3=NC4=CC=CC=C4N=C31)=O
Molecular Formula
C19H15FN4O2
Molecular Weight
350.35
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT3
Available Sizes
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