WJM664
WJM664 is a potent Plasmodium falciparum PfATP4 inhibitor. WJM664 shows strong activity against malaria parasites. WJM664 blocks gamete development and transmission to mosquitoes by inhibiting PfATP4-mediated Na+-dependent ATPase activity, and acts on multiple stages of the malaria parasite life cycle[1].
Product Specifications
UNSPSC
12352005
Target
Parasite
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(NC1=CC(OC)=C(OC)C(OC)=C1)CN2C=C(Cl)C3=C2C=C(C4=CN(C)N=C4)C(F)=C3
Molecular Formula
C23H22ClFN4O4
Molecular Weight
472.90
References & Citations
[1]Awalt JK, et al. Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4. J Med Chem. 2025 Apr 24;68 (8) :8933-8966.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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