ACC-IN-1
ACC-IN-1 (Compound B1) is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) . ACC-IN-1 targets ACC to regulate lipid metabolism, which can improve liver steatosis, inflammation related to non-alcoholic steatohepatitis (NASH) [1].
Product Specifications
CAS Number
2270839-89-7
UNSPSC
12352005
Target
Acetyl-CoA Carboxylase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(O)[C@@]1(C[C@@H](C1)N(C2=O)C(N(C3=C2C(C)=C(S3)C4=NC=CO4)C[C@H](OC5CCOCC5)C6=CC=CC=C6OC)=O)C
Molecular Formula
C30H33N3O8S
Molecular Weight
595.66
References & Citations
[1]Wang Y, et al. Identification of Novel Cyclobutane-Based Derivatives as Potent Acetyl-CoA Carboxylase Allosteric Inhibitors for Nonalcoholic Steatohepatitis Drug Discovery. J Med Chem. 2025 Apr 24;68 (8) :8578-8599.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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