ACC-IN-1

ACC-IN-1 (Compound B1) is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) . ACC-IN-1 targets ACC to regulate lipid metabolism, which can improve liver steatosis, inflammation related to non-alcoholic steatohepatitis (NASH) [1].

Product Specifications

CAS Number

[2270839-89-7]

UNSPSC

12352005

Target

Acetyl-CoA Carboxylase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

O=C(O)[C@@]1(C[C@@H](C1)N(C2=O)C(N(C3=C2C(C)=C(S3)C4=NC=CO4)C[C@H](OC5CCOCC5)C6=CC=CC=C6OC)=O)C

Molecular Formula

C30H33N3O8S

Molecular Weight

595.66

References & Citations

[1]Wang Y, et al. Identification of Novel Cyclobutane-Based Derivatives as Potent Acetyl-CoA Carboxylase Allosteric Inhibitors for Nonalcoholic Steatohepatitis Drug Discovery. J Med Chem. 2025 Apr 24;68 (8) :8578-8599.