SHP2 ATTEC degrader-1

SHP2 ATTEC degrader-1 is a SHP2 ATTEC degrader. SHP2 ATTEC degrader-1 has degradation rate of 83.31 at 1.0 μM for 24 h in the PANC-1 cell line. SHP2 ATTEC degrader-1 inhibits cell growth in vivo and in vitro. SHP2 ATTEC degrader-1 induces apoptosis and increases the expression of the epithelial marker (E-cadherin), and reduces the expression of interstitial markers (such as N-cadherin, Vimentin) (Pink: LC3 ligand (HY-174085) ; Black :linker HY-140468; Blue: SHP2 ligand (HY-174084) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; ATTECs; SHP2

Related Pathways

Apoptosis; Autophagy; PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

NC1=C(N=CC(N2CCC(C)(CC2)NC(CCOCCOCCOCCNC(CCC(NC3=CC=C(C=C3)C4=CC(OC5=C4C(O)=CC(O)=C5)=O)=O)=O)=O)=N1)C6=CSC=C6C

Molecular Formula

C43H51N7O10S

Molecular Weight

857.97

References & Citations

[1]Zhong Y, et al. Discovery of Novel SHP2 ATTEC Degraders against Pancreatic Ductal Adenocarcinoma Harboring KRAS (G12D) Mutations. J Med Chem. 2025 Apr 24;68 (8) :8143-8162.