SHP2 ATTEC degrader-1
SHP2 ATTEC degrader-1 is a SHP2 ATTEC degrader. SHP2 ATTEC degrader-1 has degradation rate of 83.31 at 1.0 μM for 24 h in the PANC-1 cell line. SHP2 ATTEC degrader-1 inhibits cell growth in vivo and in vitro. SHP2 ATTEC degrader-1 induces apoptosis and increases the expression of the epithelial marker (E-cadherin), and reduces the expression of interstitial markers (such as N-cadherin, Vimentin) (Pink: LC3 ligand ; Black :linker HY-140468; Blue: SHP2 ligand (HY-174084).
Product Specifications
UNSPSC
12352005
Target
Apoptosis; ATTECs; SHP2
Related Pathways
Apoptosis; Autophagy; PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
NC1=C(N=CC(N2CCC(C)(CC2)NC(CCOCCOCCOCCNC(CCC(NC3=CC=C(C=C3)C4=CC(OC5=C4C(O)=CC(O)=C5)=O)=O)=O)=O)=N1)C6=CSC=C6C
Molecular Formula
C43H51N7O10S
Molecular Weight
857.97
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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