AR antagonist 12
AR antagonist 12 (compound 20i) is an orally active androgen receptor antagonist wiith IC50 values of 119.3 μM and 98.2 μM for wt-AR and AR-F877L, respectively. AR antagonist 12 induces a dose-dependent and time-dependent reduction in AR, AR-V7, and PSA protein levels. AR antagonist 1 shows anticancer activuty and can be used for the study of Enzalutamide -resistant Prostate cancer[1].
Product Specifications
CAS Number
2902679-42-7
UNSPSC
12352005
Target
Androgen Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=C(NC1=CN=C(C(C(F)(F)F)=C1)C#N)[C@@](O)(CN2CC3CCC(N3C4=CC=C(C=C4)C#N)C2)C
Molecular Formula
C24H23F3N6O2
Molecular Weight
484.47
References & Citations
[1]Zhang W, et al. Discovery of Novel Bifunctional Agents as Potent Androgen Receptor Antagonists and Degraders for the Treatment of Enzalutamide-Resistant Prostate Cancer. J Med Chem. 2025 Apr 24;68 (8) :8330-8345.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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