PD-L1/HDAC3-IN-1
PD-L1/HDAC3-IN-1 (PH3) is a dual PD-L1/HDAC3 Inhibitor with IC50 values of 89.4 nM and 107 nM for PD-1/PD-L1 and HDAC3, respectively. PD-L1/HDAC3-IN-1 induces cell apoptosis and arrests cell cycle at G0/G1 phase. PD-L1/HDAC3-IN-1 shows anticancer activity both in vivo and in vitro[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; HDAC; PD-1/PD-L1
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation
Field of Research
Cancer
Smiles
CC1=C(C=CC=C1C2=CC=CC=C2)C3=NC(OC)=C(C=C3)CNCCCC(NNCCC)=O
Molecular Formula
C27H34N4O2
Molecular Weight
446.58
References & Citations
[1]Wang Z, et al. Discovery of Dual PD-L1/HDAC3 Inhibitors for Tumor Immunotherapy. J Med Chem. 2025 Apr 24;68 (8) :8046-8064.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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sc-329135 500 mg
N- (2-Methylphenyl) -1-[ (1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl) carbonyl]piperidin
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