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PRMT7-IN-2

PRMT7-IN-2 (A33) is a selective PRMT7 inhibitor with an IC50 of 0.50 μM. PRMT7-IN-2 arrests cell cycle at G0/G1 phase, induces cell apoptosis, and inhibits cell growth in vivo and in vitro. PRMT7-IN-2 decreases the monomethylarginine level of PRMT7, increases expression of epithelial marker (E-cadherin, and reduces expression of mesenchymal markers such as N-cadherin, Vimentin, and ZEB2[1].

Product Specifications

CAS Number

3058094-83-7

UNSPSC

12352005

Target

Apoptosis; Histone Methyltransferase

Related Pathways

Apoptosis; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.26

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

COC1=CC(C2=NC3=C(C(NC4=CC=C(C5=C4)N=C(C=C5N)C)=N2)SC=C3)=CC(OC)=C1OC

Molecular Formula

C25H23N5O3S

Molecular Weight

473.55

References & Citations

[1]Li J, et al. Development of Novel PRMT7 Inhibitors for the Treatment of Prostate Cancer. J Med Chem. 2025 Apr 24;68 (8) :8244-8268.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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