HDAC6-IN-54

HDAC6-IN-54 (Compound 9m) is a highly selective HDAC6 (histone deacetylase 6) inhibitor with an IC50 value of 0.021 μM. HDAC6-IN-54 blocks the activation of the NLRP3 inflammasome, which alleviates symptoms of NLRP3 inflammasome-related diseases such as acute peritonitis, inflammatory bowel disease, and psoriasis[1].

Product Specifications

UNSPSC

12352005

Target

HDAC; NOD-like Receptor (NLR)

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

FC1=C(C(NNCC)=O)C=C(F)C(CN2C3=CC=CC=C3C=CC4=C2C=NC=C4)=C1

Molecular Formula

C23H20F2N4O

Molecular Weight

406.43

References & Citations

[1]Yue K, et al. Development of Hydrazide-Based HDAC6 Selective Inhibitors for Treating NLRP3 Inflammasome-Related Diseases. J Med Chem. 2025 May 8;68 (9) :9279-9302.