HDAC6-IN-54
HDAC6-IN-54 (Compound 9m) is a highly selective HDAC6 (histone deacetylase 6) inhibitor with an IC50 value of 0.021 μM. HDAC6-IN-54 blocks the activation of the NLRP3 inflammasome, which alleviates symptoms of NLRP3 inflammasome-related diseases such as acute peritonitis, inflammatory bowel disease, and psoriasis[1].
Product Specifications
UNSPSC
12352005
Target
HDAC; NOD-like Receptor (NLR)
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
FC1=C(C(NNCC)=O)C=C(F)C(CN2C3=CC=CC=C3C=CC4=C2C=NC=C4)=C1
Molecular Formula
C23H20F2N4O
Molecular Weight
406.43
References & Citations
[1]Yue K, et al. Development of Hydrazide-Based HDAC6 Selective Inhibitors for Treating NLRP3 Inflammasome-Related Diseases. J Med Chem. 2025 May 8;68 (9) :9279-9302.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6
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