H052

H052 is a selective Staphylococcus aureus α-hemolysin (Hla) inhibitor. H052 binds to Hla monomers, disrupts the interaction with host cell membranes to block pore formation, inhibiting calcium ion influx, cytotoxicity, and inflammatory responses. H052 exhibits potency (EC50=30 nM in U937 cells) against Hla-induced calcium influx. H052 is promising for research of lung infections caused by S. aureus[1].

Product Specifications

CAS Number

[2886748-00-9]

UNSPSC

12352005

Target

Bacterial; Calcium Channel

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Infection

Smiles

O=C1NC2=C(C=C(C)C(S(NC3=CC=C(C4=CC=C(F)C=C4)C(Cl)=C3)(=O)=O)=C2)NC1=O

Molecular Formula

C21H15ClFN3O4S

Molecular Weight

459.88

References & Citations

[1]Shekhar A, et al. Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections. Cell Host Microbe. 2025 Apr 9;33 (4) :560-572.e21.