H052
H052 is a selective Staphylococcus aureus α-hemolysin (Hla) inhibitor. H052 binds to Hla monomers, disrupts the interaction with host cell membranes to block pore formation, inhibiting calcium ion influx, cytotoxicity, and inflammatory responses. H052 exhibits potency (EC50=30 nM in U937 cells) against Hla-induced calcium influx. H052 is promising for research of lung infections caused by S. aureus[1].
Product Specifications
CAS Number
2886748-00-9
UNSPSC
12352005
Target
Bacterial; Calcium Channel
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Infection
Smiles
O=C1NC2=C(C=C(C)C(S(NC3=CC=C(C4=CC=C(F)C=C4)C(Cl)=C3)(=O)=O)=C2)NC1=O
Molecular Formula
C21H15ClFN3O4S
Molecular Weight
459.88
References & Citations
[1]Shekhar A, et al. Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections. Cell Host Microbe. 2025 Apr 9;33 (4) :560-572.e21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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