KI-CDK9d-32
KI-CDK9d-32 is a CDK9 PROTAC degrader (DC50: 0.89 nM) . KI-CDK9d-32 promotes the ubiquitination and degradation of CDK9. KI-CDK9d-32 inhibits the MYC pathway and disrupts nucleolar homeostasis. KI-CDK9d-32 has anticancer activity. (Pink: CDK9 ligand (HY-153718) ; Blue: E3 ligase CRBN ligand (HY-163233) ; Black: Linker (HY-W011657) ; E3 ligase CRBN ligand-linker conjugate (HY-173525) ) [1].
Product Specifications
CAS Number
[3054009-82-1]
UNSPSC
12352005
Target
CDK; c-Myc; PROTACs
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Purity
99.0300
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@H]1C[C@H](NC2=CC(CCC)=NC3=CC=NN23)CC1)C4=CC=C(CN5CCN(C6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7)=O)C=C6)CC5)C=C4
Molecular Formula
C39H45N9O4
Molecular Weight
703.83
References & Citations
[1]Toure MA, et al. Targeted degradation of CDK9 potently disrupts the MYC-regulated network. Cell Chem Biol. 2025 Apr 17;32 (4) :542-555.e10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
Available Sizes
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