KIF2C-IN-1
KIF2C-IN-1 (compound 7S9) is a cell-penetrating, selective KIF2C inhibitor with fluorescent properties (Ex/Em = 410/510 nm). KIF2C-IN-1 exhibits notable cytotoxicity and weak inhibitory effects on KIF2A/B. KIF2C-IN-1 prohibits the dissociation of KIF2C from microtubules. KIF2C-IN-1 inhibiting KIF2C reverses cross-resistance to microtubule-targeting agents. KIF2C-IN-1 reduces tumorigenesis in chemoresistant triple-negative breast cancer (TNBC) model in mice with the combination of Paclitaxel.
Product Specifications
UNSPSC
12352005
Target
Kinesin; Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.08
Smiles
ClC1=CC=C(C2C(C(OC(C)C)=O)=C(C)N=C(S/C3=C\C4=CC=C(OCC(N5CCN(CC)CC5)=O)C=C4)N2C3=O)C=C1.OC(/C=C\C(O)=O)=O
Molecular Formula
C36H39ClN4O9S
Molecular Weight
739.23
References & Citations
[1]Pao YS, et al. KIF2C promotes paclitaxel resistance by depolymerizing polyglutamylated microtubules. Dev Cell. 2025 Mar 25:S1534-5807 (25) 00151-0.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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