SIN 14

SIN 14, a derivative of Sinomenine (HY-15122), is an orally active HO-1 activator (KD = 17.2 μM) . SIN 14 binds to the catalytic core domain of HO-1 and induces HO-1 activation in catalysis. SIN 14 significantly increases HO-1 stability. SIN 14 has anti-inflammatory effects and inhibits M1 macrophage polarization while promoting M2 polarization in LPS (Lipopolysaccharides) (HY-D1056) -induced RAW264.7 cells. SIN 14 inhibits inflammatory mediator production (eg: NO, IL-6, IL-1β and CCL2, inhibits production of ROS and down-regulates the expression of COX-2 and iNOS. SIN 14 can inhibit RA-related inflammatory edema in collagen-induced arthritis (ClA) mice[1].

Product Specifications

UNSPSC

12352005

Target

COX; Heme Oxygenase (HO) ; Interleukin Related; NO Synthase; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

COC1=CC=C2C[C@H](N3C)C4[C@@]5(CC3)C(C(O)OC1=C52)=C(Cl)C(OC)=C4

Molecular Formula

C20H22ClNO4

Molecular Weight

375.85

References & Citations

[1]Zheng YZ, et al. Discovery of sinomenine derivatives inhibiting macrophage polarization against rheumatoid arthritis through selectively targeting heme oxygenase-1. Eur J Med Chem. 2025 Aug 5;292:117596.