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NHE-1-IN-2

NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. NHE-1-IN-2 alleviates left ventricular systolic dysfunction in mice model of heart failure[1].

Product Specifications

UNSPSC

12352005

Target

Na+/H+ Exchanger (NHE)

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease

Concentration

10mM

Purity

99.57

Solubility

DMSO : 87.5 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(C2=CC=C(Cl)C(C(C3=CC=C(OCC)C=C3)=O)=C2)C=C1)NC(N)=N

Molecular Formula

C23H20ClN3O3

Molecular Weight

421.88

References & Citations

[1]Cao M, et al. Novel sodium-hydrogen exchanger 1 inhibitors with diphenyl ketone scaffold: Design, Synthesis, mechanism and evaluation in mice model of heart failure. Eur J Med Chem. 2025 Jul 5;291:117585.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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