CCR5-IN-1
CCR5-IN-1 (compound 3ad) is a selective allosteric CCR5 inhibitor with an IC50 of 1.09 μM. CCR5-IN-1 can be used in the study of cardiovascular, central nervous system, immune system, and infectious diseases[1].
Product Specifications
UNSPSC
12352005
Target
CCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Smiles
O=S(C1=C(Cl)C=CC(NC2=NC3=NON=C3N=C2NC4=CC=C(Cl)C=C4Cl)=C1O)(N(C)C)=O
Molecular Formula
C18H14Cl3N7O4S
Molecular Weight
530.77
References & Citations
[1]Billen M, et al. Discovery and exploration of disubstituted [1,2,5]oxadiazolo-[3,4-b]pyrazines as novel C-C chemokine receptor type 5 signaling inhibitors targeting the intracellular allosteric binding pocket. Eur J Med Chem. 2025 Jul 5;291:117600.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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