CCR5-IN-1

CCR5-IN-1 (compound 3ad) is a selective allosteric CCR5 inhibitor with an IC50 of 1.09 μM. CCR5-IN-1 can be used in the study of cardiovascular, central nervous system, immune system, and infectious diseases[1].

Product Specifications

UNSPSC

12352005

Target

CCR

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Field of Research

Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Smiles

O=S(C1=C(Cl)C=CC(NC2=NC3=NON=C3N=C2NC4=CC=C(Cl)C=C4Cl)=C1O)(N(C)C)=O

Molecular Formula

C18H14Cl3N7O4S

Molecular Weight

530.77

References & Citations

[1]Billen M, et al. Discovery and exploration of disubstituted [1,2,5]oxadiazolo-[3,4-b]pyrazines as novel C-C chemokine receptor type 5 signaling inhibitors targeting the intracellular allosteric binding pocket. Eur J Med Chem. 2025 Jul 5;291:117600.