FAK-IN-26
FAK-IN-26 is a BBB-penetrable Focal Adhesion Kinase (FAK) inhibitor (IC50: 0.87 nM) . FAK-IN-26 significantly suppresses tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 has potent anti-cancer activity in A549 and SKOV-3 tumor mice models with tumor inhibition rates of 59.15 % and 57.9 %[1].
Product Specifications
CAS Number
[2801785-12-4]
UNSPSC
12352005
Target
FAK
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(NC)C1=CC=CC=C1NC2=NC(NC3=CC=C(OCCF)C=C3)=NC=C2Br
Molecular Formula
C20H19BrFN5O2
Molecular Weight
460.30
References & Citations
[1] Li Y, et al. Discovery of potent focal adhesion kinase (FAK) inhibitor A8 with enhanced antitumor activity. Eur J Med Chem. 2025 Jul 5; 291:117593.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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