SARS-CoV-2 nsp13-IN-7

SARS-CoV-2 nsp13-IN-7 (Compound 6r) is a SARS-CoV-2 nsp13 inhibitor (IC50: 0.28 μM) . SARS-CoV-2 nsp13-IN-7 interferes with the helicase function of nsp13 by binding to the 5' RNA site and ATP binding site of nsp13. SARS-CoV-2 nsp13-IN-7 can be used as a lead compound for the development of antiviral drugs targeting SARS-CoV-2 nsp13[1].

Product Specifications

UNSPSC

12352005

Target

SARS-CoV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(N/N=C/C1=C(Cl)C=CC([N+]([O-])=O)=C1)C(C=C2)=CC=C2CSC3=CC=CC4=CC=CN=C43

Molecular Formula

C24H17ClN4O3S

Molecular Weight

476.93

References & Citations

[1]Fan D, et al. Discovery of 4- ((quinolin-8-ylthio) methyl) benzamide derivatives as a new class of SARS-CoV-2 nsp13 inhibitors. Bioorg Med Chem Lett. 2025 Jul 1;122:130207.