CLK2/3-IN-1
CLK2/3-IN-1 (Compound 7c) is an orally active CLK2/3 inhibitor (EC50: 5.07 nM and 30.03 nM, respectively) . CLK2/3-IN-1 binds to Lys193 and Lys186 of CLK2/3 via hydrogen bonds. CLK2/3-IN-1 can inhibit the proliferation of SW480 tumor cells (IC50: 163 nM) . CLK2/3-IN-1 can be used to study CLK-related tumor diseases[1].
Product Specifications
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
CN1C=C(C=C(C2=CC=NC(NC(C3=CC(N4CCN(C)CC4)=NC=C3)=O)=C2)C=C5)C5=N1
Molecular Formula
C24H25N7O
Molecular Weight
427.50
References & Citations
[1]Wei J, et al. Discovery of novel pyridine skeleton derivatives as potent CLK2/3 inhibitors. Bioorg Med Chem Lett. 2025 Aug 1;123:130212.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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