ATX inhibitor 27

ATX inhibitor 27 (Compound 31) is an ATX inhibitor. The IC50 values of ATX inhibitor 27 against human autotaxin (hATX) and lysophosphatidylcholine (LPC) are 13 nM and 23 nM, respectively. ATX inhibitor 27 reduces LPA levels in vivo by inhibiting ATX enzyme. ATX inhibitor 27 can be used in the study of ATX-LPA-related diseases such as inflammation, neurodegenerative diseases and cancer[1].

Product Specifications

CAS Number

[2023027-81-6]

UNSPSC

12352005

Target

LPL Receptor; Phosphodiesterase (PDE)

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Cancer; Infection; Neurological Disease; Cardiovascular Disease

Smiles

CC(N1CCC(C2=CC3=C(N=CN(CC(N(C)CC4=CC=C(C#N)C(Cl)=C4)=O)C3=O)C=C2)CC1)=O

Molecular Formula

C26H26ClN5O3

Molecular Weight

491.97

References & Citations

[1]Martin RE, et al. Optimization of a DNA encoded library derived autotaxin inhibitor hit to a potent in vivo LPA lowering quinazolinone compound with a non‑zinc binding mode. Bioorg Med Chem Lett. 2025 Aug 1;123:130221.