DS-1150b
DS-1150b is an orally active GLUT4 activator. DS-1150b has the activity of activating GLUT4 transport and can promote the translocation of GLUT4 to the cell membrane in skeletal muscle cells. DS-1150b has shown hypoglycemic effects in the Zucker obese rat model and can be used in the study of type 2 diabetes mellitus (T2DM) [1].
Product Specifications
CAS Number
[1598439-44-1]
UNSPSC
12352005
Target
GLUT
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
CC1=C(C(O)=O)C=C(C2C(C(CC(C)(C)C3)=O)=C3OC(CC(C)(C)C4)=C2C4=O)C5=C1C=C(C)O5.CC(N)(C)C
Molecular Formula
C32H41NO6
Molecular Weight
535.67
References & Citations
[1]Meguro M, et al. Discovery of DS-1150b, a novel xanthene compound for activating GLUT4 translocation. Bioorg Med Chem Lett. 2025 Jul 1;122:130191.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
GLUT4
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