EGFR-IN-157
EGFR-IN-157 (compound IIB-5) is a potent EGFR inhibitor with an IC50 of 18.81 nM. EGFR-IN-157 can be used in the study of non-small cell lung cancer (NSCLC) [1].
Product Specifications
CAS Number
3061364-63-1
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=CC(N2CCC(N3CCN(C)CC3)CC2)=C(C)C=C1NC4=NC=CC(N5N=CC(NS(=O)(C6CC6)=O)=C5)=N4
Molecular Formula
C28H39N9O3S
Molecular Weight
581.73
References & Citations
[1]Wang H, et al. Design, synthesis, and biological evaluation of novel aminopyrimidine derivatives as EGFR inhibitors. Bioorg Med Chem Lett. 2025 Jul 1;122:130188.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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