EGFR-IN-157

EGFR-IN-157 (compound IIB-5) is a potent EGFR inhibitor with an IC50 of 18.81 nM. EGFR-IN-157 can be used in the study of non-small cell lung cancer (NSCLC) [1].

Product Specifications

CAS Number

[3061364-63-1]

UNSPSC

12352005

Target

EGFR

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

COC1=CC(N2CCC(N3CCN(C)CC3)CC2)=C(C)C=C1NC4=NC=CC(N5N=CC(NS(=O)(C6CC6)=O)=C5)=N4

Molecular Formula

C28H39N9O3S

Molecular Weight

581.73

References & Citations

[1]Wang H, et al. Design, synthesis, and biological evaluation of novel aminopyrimidine derivatives as EGFR inhibitors. Bioorg Med Chem Lett. 2025 Jul 1;122:130188.