MG-3C
MG-3C is a potent matrix metalloproteinase 9 (MMP-9) inhibitor. MG-3C can selectively kill non-small-cell lung cancer (NSCLC) cells harboring the EGFR T790M mutation. MG-3C blocks the EGFR/STAT3 signaling pathway, inducing G2/M phase arrest, growth inhibition, and apoptosis of cancer cells. MG-3C is promising for research of lung cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; EGFR; MMP; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(C1=C2C(C(SC3=CC=C(/N=N\C4=CC=C(C(NCCCN5C(C=CC5=O)=O)=O)C=C4)C=C3)=CC=C26)=CC=C1)N(CCN(C)C)C6=O
Molecular Formula
C36H32N6O5S
Molecular Weight
660.74
References & Citations
[1]Li L, et al. A novel MMP-9 inhibitor exhibits selective inhibition in non-small-cell lung cancer harboring EGFR T790M mutation by blocking EGFR/STAT3 signaling pathway. Bioorg Chem. 2025 Jun 1;159:108393.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-9
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