MG-3C

MG-3C is a potent matrix metalloproteinase 9 (MMP-9) inhibitor. MG-3C can selectively kill non-small-cell lung cancer (NSCLC) cells harboring the EGFR T790M mutation. MG-3C blocks the EGFR/STAT3 signaling pathway, inducing G2/M phase arrest, growth inhibition, and apoptosis of cancer cells. MG-3C is promising for research of lung cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; EGFR; MMP; STAT

Related Pathways

Apoptosis; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C(C1=C2C(C(SC3=CC=C(/N=N\C4=CC=C(C(NCCCN5C(C=CC5=O)=O)=O)C=C4)C=C3)=CC=C26)=CC=C1)N(CCN(C)C)C6=O

Molecular Formula

C36H32N6O5S

Molecular Weight

660.74

References & Citations

[1]Li L, et al. A novel MMP-9 inhibitor exhibits selective inhibition in non-small-cell lung cancer harboring EGFR T790M mutation by blocking EGFR/STAT3 signaling pathway. Bioorg Chem. 2025 Jun 1;159:108393.