AR ligand 40

AR ligand 40 (compound 19c) is an Adenosine A1 Receptor ligand with antagonist activity. AR ligand 40 exhibits antiproliferative effect on SW480, SW48, HCT116, K562, MDA-MB-231, and A549 cells with EC50s of 7, 10, 12, 13, 15 and 39 μM[1].

Product Specifications

UNSPSC

12352005

Target

Adenosine Receptor

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

C1(NC2=C3C(N(C4CCCC4)C(C5=CC=CC=C5)=N3)=NC=N2)CCCC1

Molecular Formula

C21H25N5

Molecular Weight

347.46

References & Citations

[1]Córdoba-Gómez LB, et al. Exploring Trisubstituted adenine derivatives as adenosine A1 receptor ligands with antagonist activity: Synthesis, biological evaluation and molecular modelling. Bioorg Chem. 2025 Jun 1;159:108395.