GSK-3β/CK-1δ-IN-1
GSK-3β/CK-1δ-IN-1 (8d) is a dual and blood-brain barrier penetrated GSK-3β / CK-1δ inhibitor, with IC50 values of 0.77 μM for GSK-3β and 0.57 μM for CK-1δ, respectively. GSK-3β/CK-1δ-IN-1 (8d) can be used in the research for neuroblastoma[1].
Product Specifications
UNSPSC
12352005
Target
Casein Kinase; GSK-3
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(NC1=CC=CC2=C1C=CN2C)C3=CN=C(N)C(C4=CC=CC=C4C(F)(F)F)=C3
Molecular Formula
C22H17F3N4O
Molecular Weight
410.39
References & Citations
[1]Vinita Sharma, et al. Discovery of 6-amino pyridine clubbed heterocycles as potent dual GSK-3β/CK-1δ inhibitors for the treatment of Alzheimer's disease. Bioorg Chem. 2025 Jun 1:159:108409.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1; GSK-3β
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