CXCR2/CCR7 antagonist-1

CXCR2/CCR7 antagonist-1 (compound 6) is a potent CXCR2 and CCR7 dual antagonist with IC50s of 0.0046 and 0.0014 μM, respectively. CXCR2/CCR7 antagonist-1 can be used in the study of cancer metastasis and autoimmune diseases[1].

Product Specifications

CAS Number

[473728-04-0]

UNSPSC

12352005

Target

CCR; CXCR

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Field of Research

Cancer; Inflammation/Immunology

Smiles

OC1=C(C(N(C)C)=O)C=CC=C1NC2=C(N[C@H](C(C)(C)C)C3=CC=C(C)O3)C(C2=O)=O

Molecular Formula

C23H27N3O5

Molecular Weight

425.48

References & Citations

[1]Meden A, et al. Structure-activity relationship study of navarixin analogues as dual CXCR2 and CCR7 antagonists. Bioorg Chem. 2025 Jun 1;159:108423.