Wnt/β-catenin-IN-5

Wnt/β-catenin-IN-5 (compound 19T) is a Wnt/β-catenin signaling pathway inhibitor. Wnt/β-catenin-IN-5 inhibits HCT 116, SW480, and A549 cells activity with IC50s of 3.05, 3.27 and 34.91 μM, respectively[1].

Product Specifications

CAS Number

[2805248-10-4]

UNSPSC

12352005

Target

Wnt; β-catenin

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

OC1=C(O)C=C(C(OC2=C(Br)C=C(Cl)C=C2C3=CC=NO3)=O)C=C1

Molecular Formula

C16H9BrClNO5

Molecular Weight

410.60

References & Citations

[1]Dong L, et al. Structure-activity relationship explorations of 2- (isoxazol-5-yl) phenyl-3,4-dihydroxybenzoate derivatives to develop potent Wnt/β-catenin pathway inhibitors for colorectal cancer treatment. Bioorg Chem. 2025 Jun 15;160:108433.