Wnt/β-catenin-IN-5
Wnt/β-catenin-IN-5 (compound 19T) is a Wnt/β-catenin signaling pathway inhibitor. Wnt/β-catenin-IN-5 inhibits HCT 116, SW480, and A549 cells activity with IC50s of 3.05, 3.27 and 34.91 μM, respectively[1].
Product Specifications
CAS Number
2805248-10-4
UNSPSC
12352005
Target
Wnt; β-catenin
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OC1=C(O)C=C(C(OC2=C(Br)C=C(Cl)C=C2C3=CC=NO3)=O)C=C1
Molecular Formula
C16H9BrClNO5
Molecular Weight
410.60
References & Citations
[1]Dong L, et al. Structure-activity relationship explorations of 2- (isoxazol-5-yl) phenyl-3,4-dihydroxybenzoate derivatives to develop potent Wnt/β-catenin pathway inhibitors for colorectal cancer treatment. Bioorg Chem. 2025 Jun 15;160:108433.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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