ATX inhibitor 26

ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. ATX inhibitor 26 inhibits cell migration and collagen gel contraction. ATX inhibitor 26 has significant anti-fibrotic effects, reducing collagen deposition in a Bleomycin (BLM) (HY-108345) -induced pulmonary fibrosis model[1].

Product Specifications

CAS Number

[2940248-11-1]

UNSPSC

12352005

Target

ERK; JNK; p38 MAPK; Phosphodiesterase (PDE)

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

ClC1=CC(Cl)=CC(COC(N2CCC(C3=NN=C(NCC4=CN=NN4)O3)CC2)=O)=C1

Molecular Formula

C18H19Cl2N7O3

Molecular Weight

452.29

References & Citations

[1]Kim M, et al. Targeting Autotaxin with imidazole- and Triazolyl-based inhibitors: Biological insights from in vitro and in vivo studies in pulmonary fibrosis. Bioorg Chem. 2025 Jun 15; 160:108426.