TNKS-IN-3
TNKS-IN-3 (Compound 6) is a TNKS2 inhibitor (Ki: 8.5 nM) . TNKS-IN-3 has good activity (IC50: 71 nM) and can effectively inhibit the WNT/β-catenin signaling pathway. TNKS-IN-3 can be used in the research of diseases such as cancer and fibrosis[1].
Product Specifications
UNSPSC
12352005
Target
PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
O=C(NC1=CC=CC=C1OC)C2=CC=C(NC(N(CCC(N3)=NC4=C(C=CC=C4)C3=O)CC5=CC=CS5)=O)C=C2
Molecular Formula
C30H27N5O4S
Molecular Weight
553.63
References & Citations
[1]Sowa ST, et al. Deconstruction of Dual-Site Tankyrase Inhibitors Provides Insights into Binding Energetics and Suggests Critical Hotspots for Ligand Optimization. J Med Chem. 2025 Apr 10;68 (7) :7263-7279.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNKS2/PARP5B
Curated Selection
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