GLP-1R agonist 30

GLP-1R agonist 30 is a selective and orally active GLP-1R agonist with an EC50 of 0.048 nM. GLP-1R has excellent selectivity, with EC50 greater than 20 μM for GLP-2R, GIPR, and GCPR. GLP-1R agonist significantly increases cAMP-stimulating activity while markedly reducing hERG inhibitory activities. GLP-1R agonist has preferable absorption and excellent β-arrestin pathway selectivity. GLP-1R agonist effectively improves glucose tolerance and promoted insulin secretion in B-hGLP1R knock-in mice[1].

Product Specifications

UNSPSC

12352005

Target

GLP Receptor

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Smiles

FC1=C(COC2=CC=CC(C3=CCN(CC3)CC4=NC5=C(N=C(C=C5)C(O)=O)N4C[C@H]6OCC6)=N2)C=CC(C7CC(F)(C7)F)=C1

Molecular Formula

C33H32F3N5O4

Molecular Weight

619.63

References & Citations

[1]Miao L, et al. Discovery of New Difluorocyclobutyl Derivatives as Effective Glucagon-Like Peptide-1 Receptor Agonists with Reduced hERG Inhibitory Activities. J Med Chem. 2025 Apr 10; 68 (7) :7662-7692.|[2]Miao L, et al. Discovery of New Difluorocyclobutyl Derivatives as Effective Glucagon-Like Peptide-1 Receptor Agonists with Reduced hERG Inhibitory Activities. J Med Chem. 2025 Apr 10; 68 (7) :7662-7692.