GLP-1R agonist 30
GLP-1R agonist 30 is a selective and orally active GLP-1R agonist with an EC50 of 0.048 nM. GLP-1R has excellent selectivity, with EC50 greater than 20 μM for GLP-2R, GIPR, and GCPR. GLP-1R agonist significantly increases cAMP-stimulating activity while markedly reducing hERG inhibitory activities. GLP-1R agonist has preferable absorption and excellent β-arrestin pathway selectivity. GLP-1R agonist effectively improves glucose tolerance and promoted insulin secretion in B-hGLP1R knock-in mice[1].
Product Specifications
UNSPSC
12352005
Target
GLP Receptor
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Smiles
FC1=C(COC2=CC=CC(C3=CCN(CC3)CC4=NC5=C(N=C(C=C5)C(O)=O)N4C[C@H]6OCC6)=N2)C=CC(C7CC(F)(C7)F)=C1
Molecular Formula
C33H32F3N5O4
Molecular Weight
619.63
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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