TcO-ABX474

TcO-ABX474 (TcO-5) is a potent prostate-specific membrane antigen (PSMA) inhibitor with a Kd value of 6.1 nM. TcO-ABX474 inhibits prostate cancer cell growth and metastasis. TcO-ABX474 is promising for research of prostate cancer[1].

Product Specifications

CAS Number

[3019987-06-2]

Product Name Alternative

TcO-5

UNSPSC

12352211

Target

PSMA

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(CC[C@H](C(O)=O)NC(N[C@@H](C(O)=O)CCCCNC(CCCCCCC(NCCCC[C@H](NC([C@H](NC([C@@H](NC(CCCC[N]1(CC(C)(C)S2)CCN(CC(C)(C)S3)[Tc]132=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)C(O)=O)=O)=O)=O)O

Molecular Formula

C51H86N9O19S2Tc

Molecular Weight

1292.31

References & Citations

[1]Lis C, et al. Development of [99mTc]TcO-ABX474: Design, Synthesis, and Biological Evaluation of PSMA-Binding Technetium-99m Radioligands for SPECT Imaging of Prostate Cancer. J Med Chem. 2025 Apr 10;68 (7) :7213-7231.