ERβ agonist-1

ERβ agonist-1 (Compound 8) is a dual-active selective ERβ agonist (EC50: 46.8 nM) and AR antagonist (IC50: 1555 nM) . ERβ agonist-1 activates ERβ signaling by binding to ERβ and inhibits AR activity. ERβ agonist-1 retains selective ERβ agonist activity in mouse models and can be used to study prostate cancer[1].

Product Specifications

CAS Number

[2412715-30-9]

UNSPSC

12352005

Target

Androgen Receptor; Estrogen Receptor/ERR

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

CC(CCC[C@]12C(C[C@H](C1)O)=C3CCC4=C(C(O)=CC=C4[C@]3(CC2)C)C)C

Molecular Formula

C25H36O2

Molecular Weight

368.55

References & Citations

[1]Bucknam AR, et al. An Estrogen Receptor β Agonist with AR Antagonist Activity from a Modern Asymmetric De Novo Steroid Synthesis. ACS Med Chem Lett. 2025 Mar 27;16 (4) :631-637.