ERβ agonist-1
ERβ agonist-1 (Compound 8) is a dual-active selective ERβ agonist (EC50: 46.8 nM) and AR antagonist (IC50: 1555 nM) . ERβ agonist-1 activates ERβ signaling by binding to ERβ and inhibits AR activity. ERβ agonist-1 retains selective ERβ agonist activity in mouse models and can be used to study prostate cancer[1].
Product Specifications
CAS Number
2412715-30-9
UNSPSC
12352005
Target
Androgen Receptor; Estrogen Receptor/ERR
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
CC(CCC[C@]12C(C[C@H](C1)O)=C3CCC4=C(C(O)=CC=C4[C@]3(CC2)C)C)C
Molecular Formula
C25H36O2
Molecular Weight
368.55
References & Citations
[1]Bucknam AR, et al. An Estrogen Receptor β Agonist with AR Antagonist Activity from a Modern Asymmetric De Novo Steroid Synthesis. ACS Med Chem Lett. 2025 Mar 27;16 (4) :631-637.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERβ
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