MBL-IN-5

MBL-IN-5 is a metallo-β-lactamase (MBL) inhibitor. MBL-IN-5 inhibits three clinically relevant B1 subfamily MBLs (NDM-1, VIM-1, and IMP-1) with IC50s of 0.05 nM, 14 nM and 21 nM respectively. MBL-IN-5 remarkably enhances carbapenems’ effectiveness against MBL-producing clinical strains and significantly reduces the bacterial load in a neutropenic murine thigh infection model combined with the IPM antibiotic[1].

Product Specifications

CAS Number

[2876921-34-3]

UNSPSC

12352005

Target

Bacterial; Beta-lactamase

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C(C1=C(C2=C(OC)C=CC(Cl)=C2)C3=C(C4=C(CC3)C=CC=C4)N1)O

Molecular Formula

C20H16ClNO3

Molecular Weight

353.80

References & Citations

[1]Dhiman P, et al. Discovery of Conformationally Constrained Dihydro Benzo-Indole Derivatives as Metallo-β-Lactamase Inhibitors to Tackle Multidrug-Resistant Bacterial Infections. J Med Chem. 2025 Apr 10;68 (7) :7062-7081.