TRPA1 agonist-1
TRPA1 agonist-1 (compound 21) is a potent and selective TAAR1 agonist with an EC50 of 25.47 μM. TRPA1 agonist-1 shows effective analgesic properties without irritation in mice[1].
Product Specifications
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CCC1=CC=C(C2=CSC(NCCCOC)=N2)C=C1
Molecular Formula
C15H20N2OS
Molecular Weight
276.40
References & Citations
[1]Yang N, et al. Discovery of non-electrophilic TRPA1 channel agonists with anti-nociceptive effects via rapid current desensitization. Eur J Med Chem. 2025 Jul 5;291:117586.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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