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TRPA1 agonist-1

TRPA1 agonist-1 (compound 21) is a potent and selective TAAR1 agonist with an EC50 of 25.47 μM. TRPA1 agonist-1 shows effective analgesic properties without irritation in mice[1].

Product Specifications

UNSPSC

12352005

Target

TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CCC1=CC=C(C2=CSC(NCCCOC)=N2)C=C1

Molecular Formula

C15H20N2OS

Molecular Weight

276.40

References & Citations

[1]Yang N, et al. Discovery of non-electrophilic TRPA1 channel agonists with anti-nociceptive effects via rapid current desensitization. Eur J Med Chem. 2025 Jul 5;291:117586.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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