LT-188A
LT-188A is a potent TGR5 agonist with an EC50 of 23 μM. LT-188A decreases the levels of inflammatory mediators in macrophages[1].
Product Specifications
CAS Number
[2922530-99-0]
UNSPSC
12352005
Target
G protein-coupled Bile Acid Receptor 1
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
COC1=C(OC)C=C(C[C@H]2CO[C@H](C3=CC(OC)=C(OC)C=C3)[C@H]2CCOC(/C(C)=C\C)=O)C=C1
Molecular Formula
C28H36O7
Molecular Weight
484.58
References & Citations
[1]Perhal AF, et al. dentification and Characterization of a Leoligin-Inspired Synthetic Lignan as a TGR5 Agonist. J Nat Prod. 2025 Apr 25;88 (4) :985-995.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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