DL5055

DL5055 (compound 6k) is a potent and selective hCAR activator with an EC50 of 0.35 μM. DL5055 induces CYP2B6 expression and hCAR nuclear translocation in human primary hepatocytes[1].

Product Specifications

CAS Number

[2259710-89-7]

UNSPSC

12352005

Target

Constitutive Androstane Receptor

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Smiles

O=C(NC1CC2=C(C=CC=C2)C1)C3=C(C4=CC=C5C=CC=CC5=C4)N=C6OC=CN36

Molecular Formula

C25H19N3O2

Molecular Weight

393.44

References & Citations

[1]Liang D, et al. Potent and Selective Human Constitutive Androstane Receptor Activator DL5055 Facilitates Cyclophosphamide-Based Chemotherapies. J Med Chem. 2025 Apr 10;68 (7) :7044-7061.