PD-1/PD-L1-IN-55

PD-1/PD-L1-IN-55 (compound D6) is a potent PD-1/PD-L1 inhibitor with an IC50 of 4.8 nM. PD-1/PD-L1-IN-55 promotes IFN-γ secretion and reduces the proportion of PD-L1 late apoptosis[1].

Product Specifications

CAS Number

[3052262-83-3]

UNSPSC

12352005

Target

PD-1/PD-L1

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Smiles

C[C@H](N)C(N1CC2=CC(C3=C(C(C4=CC=C(OCCO5)C5=C4)=CC=C3)Cl)=CC=C2C1)=O

Molecular Formula

C25H23ClN2O3

Molecular Weight

434.91

References & Citations

[1]Lu T, et al. Design, Synthesis, Evaluation, and SAR of 5-Phenylisoindoline Derivatives, a Potent Class of Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 (PD-1/PD-L1) Interaction. J Med Chem. 2025 Apr 10;68 (7) :7291-7312.